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Association between the insertion/deletion polymorphism of the angiotensin I‐converting enzyme gene and risk for psoriasis in a Chinese population in Taiwan
Author(s) -
Chang YC.,
Wu WM.,
Chen CH.,
Lee SH.,
Hong HS.,
Hsu LA.
Publication year - 2007
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2006.07716.x
Subject(s) - psoriasis , angiotensin converting enzyme , genotype , allele , medicine , angiotensin ii , allele frequency , genetic predisposition , gene polymorphism , genotype frequency , population , immunology , gastroenterology , endocrinology , genetics , gene , biology , blood pressure , disease , environmental health
Summary Background Genetic factors play an important role in susceptibility for psoriasis. The angiotensin I‐converting enzyme (ACE) is expressed by keratinocytes. Administration of ACE inhibitors may induce or exacerbate psoriasis in clinical practice. Thus, ACE gene variants may contribute to the genetic background of psoriasis. Objectives To assess the role of the ACE insertion/deletion (I/D) polymorphism in psoriasis among ethnically Chinese Taiwanese subjects. Methods In total, 312 patients with psoriasis and 615 control subjects were analysed for the ACE I/D polymorphism by polymerase chain reaction. Results A marginally significant difference ( P = 0·035) was found in the distribution of ACE I/D genotype frequencies between patients with psoriasis and controls. The frequency of the II genotype in patients with psoriasis was significantly higher than that in the control group (55·1% vs. 46·7%, respectively, P = 0·015). Although the I allele frequency in patients with psoriasis (72·4%) was higher than that in the control group (68·2%), the difference was not significantly different ( P = 0·062). After adjusting for age and gender, carriers of the II genotype were 1·45 (95% confidence interval 1·09–1·92) times more likely than noncarriers to have psoriasis ( P = 0·010). Conclusions Our results suggest that the presence of the I allele may confer susceptibility to development of psoriasis among ethnically Chinese Taiwanese individuals.