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Association between cutaneous melanoma, Breslow thickness and vitamin D receptor Bsm I polymorphism
Author(s) -
Santonocito C.,
Capizzi R.,
Concolino P.,
Lavieri M.M.,
Paradisi A.,
Gentileschi S.,
Torti E.,
Rutella S.,
Rocchetti S.,
Di Carlo A.,
Di Stasio E.,
Ameglio F.,
Zuppi C.,
Capoluongo E.
Publication year - 2007
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2006.07620.x
Subject(s) - foki , calcitriol receptor , taqi , genotype , medicine , single nucleotide polymorphism , oncology , restriction fragment length polymorphism , logistic regression , vitamin d and neurology , polymorphism (computer science) , gastroenterology , biology , genetics , gene
Summary Background Literature data report an association between some vitamin D receptor (VDR) polymorphisms and different kinds of tumours, including malignant melanoma (MM). Only three VDR polymorphisms ( Fok I, Taq I and A‐1012G) have been investigated in association with the presence of cutaneous MM or the development of metastases. Objectives The present paper analyses for the first time the association between Bsm I polymorphism and MM prevalence together with Breslow thickness. In addition, the Fok I single nucleotide polymorphism was also determined. Methods One hundred and one patients with MM and 101 healthy donors matched for age and sex were enrolled. Molecular VDR typing was performed by means of restriction fragment length polymorphism analysis. Results All cases and controls were in Hardy–Weinberg equilibrium for Bsm I, Fok I and A‐1012G. Significant associations were found between the Bsm I bb genotype frequency and MM ( P = 0·02) along with Breslow thickness ( P = 0·001). This same behaviour was not observed for the Fok I or A‐1012G polymorphisms. Multivariate logistic regression analysis confirmed these significant results after correction for age, gender, skin type and MM localization. Conclusions Although the biological meaning of the effects exerted by Bsm I polymorphism is still under debate, the statistical association found in the present study suggests that further work should be done to verify this variant as a possible risk marker for MM and its aggressiveness, also considering that the real association may be due to other unknown genes linked to the Bsm I b allele.