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Absent/reduced glucose transporter‐1 protein expression in infantile subglottic haemangiomas
Author(s) -
Purvis D.J.,
Harper J.I.,
Hartley B.E.,
Sebire N.J.
Publication year - 2006
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2006.07468.x
Subject(s) - glut1 , medicine , immunostaining , pathology , immunohistochemistry , staining , glucose transporter , insulin
Summary Background Positive immunohistochemical staining for glucose transporter‐1 protein (GLUT1) is a characteristic of cutaneous infantile haemangiomas. Objectives To examine GLUT1 expression in subglottic haemangiomas. Methods Review of clinical notes and biopsy tissue with immunostaining for GLUT1 in 14 patients with subglottic haemangiomas. Results GLUT1 immunostaining was negative in 11 cases, and focally positive in three. No subglottic haemangiomas demonstrated the intense diffuse positive GLUT1 staining seen in cutaneous infantile haemangiomas. Five patients had cutaneous as well as subglottic haemangiomas, one of whom had a GLUT1‐negative subglottic haemangioma and a GLUT1‐positive cutaneous haemangioma of the lip. Conclusions Subglottic haemangiomas appear immunohistochemically different from cutaneous infantile haemangiomas, which may reflect differences in endothelial cell differentiation or underlying aetiology.