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Atypical cutaneous leishmaniasis in two patients receiving low‐dose methotrexate
Author(s) -
Saha M.,
Shipley D.,
McBride S.,
Kennedy C.,
VegaLopez F.
Publication year - 2006
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2006.07418.x
Subject(s) - methotrexate , cutaneous leishmaniasis , leishmaniasis , medicine , dermatology , disease , immunology , leishmania , parasite hosting , world wide web , computer science
Summary Cutaneous leishmaniasis is a protozoan disease that has high morbidity. There have been increasing reports of leishmaniasis in patients with an underlying immunosuppressed state. We present two cases of cutaneous leishmaniasis caused by Old World species in patients on methotrexate therapy. We postulate that the T‐cell‐mediated response to leishmaniasis infection could be modulated by methotrexate and may render an immunosuppressed individual more susceptible to developing clinical disease.