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Subcutaneous hyalohyphomycosis due to Cephalotheca foveolata in an immunocompetent host
Author(s) -
Suh M.K.,
Lim J.W.,
Lee Y.H.,
Ha G.Y.,
Kim H.,
Kim J.R.,
Yaguchi T.,
Nishimura K.
Publication year - 2006
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2006.07158.x
Subject(s) - dermis , histopathology , granulomatous inflammation , biopsy , pathology , dorsum , biology , skin biopsy , antifungal , spore , granuloma , dermatology , medicine , anatomy , microbiology and biotechnology
Summary We report the first case of subcutaneous hyalohyphomycosis caused by the genus Cephalotheca , which has not been reported to cause human infection. A 67‐year‐old immunocompetent farmer presented with a 10‐year history of verrucous erythematous plaques on the right foot dorsum, great toe, heel and sole. Histopathology of the lesions revealed chronic granulomatous inflammation with numerous nonpigmented fungal spores in the dermis. Cultures of biopsy specimens on Sabouraud's dextrose agar for 2 weeks developed into yellowish brown, velvety colonies that subsequently turned black after 8 weeks because of the production of black cleistothecia indicating the teleomorph. On the basis of mycological features, scanning electron microscopic morphology and molecular analysis data, a new species of Cephalotheca was identified and designated Cephalotheca foveolata . Because there was no response to the antifungal agents administered, the patient was successfully treated by surgical excision with skin graft.