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HLA Cw*06 is not essential for streptococcal‐induced psoriasis
Author(s) -
Fry L.,
Powles A.V.,
Corcoran S.,
Rogers S.,
Ward J.,
Unsworth D.J.
Publication year - 2006
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2005.07101.x
Subject(s) - psoriasis , medicine , pathogenesis , incidence (geometry) , immunology , group a , dermatology , physics , optics
Summary Background Streptococcal throat infections and HLA Cw6 (Cw*06) have been implicated in the pathogenesis of psoriasis, particularly in the guttate form. Objectives To study 105 Irish patients with psoriasis to investigate the relationship between streptococcal infections and Cw*06. Methods The patients were divided into two groups: those with guttate psoriasis or guttate flare (guttate group, GG, n = 64) and those with chronic plaque psoriasis (chronic plaque group, CPG, n = 41). Results The incidence of Cw*06 was 86% in the GG and 73% in the CPG, which was not significantly different ( P = 0·1725) but the incidence in both groups was significantly higher than in an Irish control group (18%) ( P < 0·0001 vs. GG and P < 0·0001 vs. CPG). Evidence for streptococcal infection was higher in the GG (56%) than in the CPG (32%) ( P = 0·0231). Of those patients with evidence of streptococcal infection, 30 of 36 GG (83%) and nine of 13 CPG (69%) patients possessed the Cw*06 genotype. Conclusions Thus, not all patients with streptococcal‐related psoriasis carry Cw*06. The role of Cw*06 in psoriasis, if any, has yet to be determined.