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Onychomycosis caused by Fusarium proliferatum
Author(s) -
Hattori N.,
Shirai A.,
Sugiura Y.,
Li W.,
Yokoyama K.,
Misawa Y.,
Okuzumi K.,
Tamaki K.
Publication year - 2005
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2005.06692.x
Subject(s) - fusarium proliferatum , itraconazole , medicine , fungus , nail (fastener) , dermatology , fusarium oxysporum , fusarium , biology , antifungal , botany , materials science , metallurgy
Summary Fusarium infections in humans are usually opportunistic, but the fungus sometimes infects healthy persons, causing keratomycosis or onychomycosis. Onychomycosis is usually caused by F. solani or F. oxysporum . We report the first two cases of onychomycosis caused by F. proliferatum , and discuss methods of diagnosis and effective treatment. Nail samples from the two patients were examined by direct microscopy, cultured, and identified morphologically and genetically as F. proliferatum . Both patients were treated successfully with oral itraconazole, even though the minimum inhibitory concentration of itraconazole was relatively high in Patient 1. This is the first report of F. proliferatum as an agent of onychomycosis. Itraconazole may be effective in the treatment of onychomycosis caused by F. proliferatum .