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Molecular aetiology and pathogenesis of basal cell carcinoma
Author(s) -
Tilli C.M.L.J.,
Van Steensel M.A.M.,
Krekels G.A.M.,
Neumann H.A.M.,
Ramaekers F.C.S.
Publication year - 2005
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2005.06587.x
Subject(s) - basal cell carcinoma , pathogenesis , carcinogenesis , biology , epidermis (zoology) , cell , appendage , apoptosis , cell growth , cancer research , pathology , bioinformatics , microbiology and biotechnology , genetics , basal cell , medicine , immunology , gene , anatomy
Summary Recent insights into the cell biology of the epidermis and its appendages are transforming our understanding of the pathogenesis of basal cell carcinoma (BCC). The significant progress that has been made warrants a comprehensive review of the molecular and cellular pathology of BCC. The items addressed include environmental and genetic risk factors, the biology of the putative precursor cell(s), and the contribution of aberrations in processes such as apoptosis, cell proliferation, differentiation and signalling to carcinogenesis. Furthermore, established and novel treatment modalities are discussed with particular attention to future biological approaches.