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Treatment of advanced malignant eccrine poroma with locoregional chemotherapy
Author(s) -
De Bree E.,
Volalakis E.,
Tsetis D.,
Varthalitis Y.,
Panagiotidis J.,
Romanos J.,
Tsiftsis D.D.
Publication year - 2005
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2005.06472.x
Subject(s) - medicine , docetaxel , chemotherapy , malignant disease , fluorouracil , dermatology , systemic disease , disease , oncology , cancer
Summary Malignant eccrine poroma is a rare disease with approximately 200 cases reported in the literature. Regional cutaneous and systemic metastases are rarely observed and their management has been generally unsuccessful. We report on a case in which topical 5‐fluorouracil application and intra‐arterial chemotherapy with docetaxel resulted in a histologically confirmed complete response of multiple regional skin metastases for more than 2 years. Despite intravenous administration of docetaxel, slow progression of systemic disease was observed.