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Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature
Author(s) -
Beltraminelli H.S.,
Lerch M.,
Arnold A.,
Bircher A.J.,
Haeusermann P.
Publication year - 2005
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2005.06393.x
Subject(s) - acute generalized exanthematous pustulosis , terbinafine , toxic epidermal necrolysis , dermatology , medicine , drug eruption , drug , drug reaction , pustulosis , adverse drug reaction , antifungal , pharmacology , immunology , itraconazole , arthritis , synovitis
Summary Cutaneous drug reactions occur with a frequency of 1–8% and can be higher for certain classes of drugs. They can range from mild morbilliform eruptions to more severe forms such as drug‐hypersensitivity syndrome, toxic epidermal necrolysis or anaphylaxis. Acute generalized exanthematous pustulosis (AGEP) is considered to be a clinical reaction pattern, which is induced in over 90% of the cases by systemic drugs. It is a rare presentation of an adverse drug reaction most frequently triggered by anti‐infectious drugs. A high proportion of these cases have been attributed to aminopenicillins and macrolides. We report a terbinafine‐induced AGEP in a 68‐year‐old male confirmed by lymphocyte stimulation in vitro , and review the published cases induced by antimycotic drugs with special emphasis on terbinafine‐triggered cases.