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The impact of a two‐compound product containing calcipotriol and betamethasone dipropionate (Daivobet ® / Dovobet ® ) on the quality of life in patients with psoriasis vulgaris: a randomized controlled trial
Author(s) -
Van De Kerkhof P.C.M.
Publication year - 2004
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2004.06134.x
Subject(s) - calcipotriol , betamethasone dipropionate , medicine , psoriasis , visual analogue scale , placebo , quality of life (healthcare) , dermatology life quality index , betamethasone , randomized controlled trial , corticosteroid , physical therapy , dermatology , alternative medicine , pathology , nursing
Summary Background Psoriasis is a common disease and may have a significant impact on patients' quality of life (QoL). Objectives To assess the impact on QoL of a new two‐compound product (TCP) (Daivobet ® /Dovobet ® ; LEO Pharma) which combines the topical vitamin D analogue calcipotriol (50 µg g −1 ) and the World Health Organization group III corticosteroid betamethasone dipropionate (0·5 mg g −1 ) in a single ointment vs. calcipotriol monotherapy using a placebo‐controlled study design. Methods The Psoriasis Disability Index and the EuroQoL 5D questionnaire and visual analogue scale (VAS) were used in this study, which enrolled 828 patients with psoriasis vulgaris for treatment lasting up to 4 weeks. These QoL instruments were completed by patients before and after treatment with the TCP of calcipotriol and betamethasone dipropionate used once or twice daily, calcipotriol alone twice daily and vehicle twice daily. Results The TCP used once or twice daily and calcipotriol used twice daily were found to have statistically significant beneficial effects on patients' QoL over the course of treatment, and each was demonstrated to have a statistically significant benefit on QoL over vehicle. The TCP, applied once daily, was superior to calcipotriol twice daily in terms of reductions on the EuroQoL 5D questionnaire and VAS. Conclusions The results suggest that calcipotriol twice daily and the new TCP applied twice daily have a substantial effect on QoL. Once‐daily application of the TCP is superior to calcipotriol twice daily terms of QoL, which reflects the superior efficacy of this combination and the advantage of once‐daily application when compared with twice‐daily application.