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A pilot study of treatment of lentigo maligna with 5% imiquimod cream
Author(s) -
Fleming C.J.,
Bryden A.M.,
Evans A.,
Dawe R.S.,
Ibbotson S.H.
Publication year - 2004
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2004.05983.x
Subject(s) - imiquimod , lentigo maligna , medicine , lentigo maligna melanoma , dermatology , grading (engineering) , lesion , surgery , melanoma , civil engineering , cancer research , engineering
Summary Background Lentigo maligna (LM) is an in situ form of malignant melanoma, and surgical excision is often unsatisfactory. Imiquimod cream is an immune response modifier and induces a predominantly T‐helper 1 type response. Objectives Assessment of histological and clinical response of surgically resectable LM after treatment with 5% imiquimod cream. Methods Six patients with LM were treated with 5% imiquimod cream daily for 6 weeks. The whole site of the original lesion was then excised. Clinical and histological and appearances were measured using clinical response and histological grading scores. Results Complete or almost complete clearance of pigmentation with minimal residual histological evidence of LM was observed in four patients, one patient showed no clinical or histological improvement, and the remaining patient had almost no residual pigmentation clinically after treatment yet histopathological changes remained as severe as before treatment. Conclusions Topical imiquimod cream merits further investigation as a new therapy for LM.