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Nail dystrophy, an unusual presentation of incontinentia pigmenti
Author(s) -
Nicolaou N.,
GrahamBrown R.A.C.
Publication year - 2003
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2003.05694.x
Subject(s) - incontinentia pigmenti , genodermatosis , dermatology , dystrophy , medicine , nail (fastener) , presentation (obstetrics) , genetics , pathology , biology , surgery , gene , materials science , metallurgy
Summary We describe a 57‐year‐old woman with a history of nail dystrophy since the age of 11 years. Multiple nail clippings were negative and multiple empirical treatments for presumed onychomycosis were unsuccessful. The patient has a daughter with classical incontinentia pigmenti. Molecular genetic analysis was positive for the NEMO gene deletion on the X chromosome, confirming the diagnosis of incontinentia pigmenti. Nail dystrophy was the sole feature of the disease in our patient.