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Granulocyte colony‐stimulating factor‐producing cutaneous angiosarcoma with leukaemoid reaction arising on a burn scar
Author(s) -
Nara T.,
Hayakawa A.,
Ikeuchi A.,
Katoh N.,
Kishimoto S.
Publication year - 2003
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2003.05684.x
Subject(s) - angiosarcoma , pathology , immunohistochemistry , granulocyte colony stimulating factor , dermis , medicine , pathological , staining , chemotherapy
Summary We report a 46‐year‐old man with a giant tumour in a burn scar on his buttock. Pathological examination revealed that the dermis was filled with anastomosing vascular channels and round‐ or spindle‐type atypical cells, which were compatible with the diagnosis of cutaneous angiosarcoma. Based on prominent leucocytosis (up to 113 000 μL −1 ), we measured serum granulocyte colony‐stimulating factor (G‐CSF). The highly elevated serum G‐CSF of 303 ng L −1 (normal, 6·1–21·5 ng L −1 ) and positive immunohistochemical staining of the tumour tissue for G‐CSF indicated that G‐CSF was produced by the cutaneous angiosarcoma. To our knowledge, this is the first reported case of G‐CSF‐producing cutaneous angiosarcoma.