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Henoch–Schönlein purpura in pregnancy
Author(s) -
Cummins D.L.,
Mimouni D.,
Rencic A.,
Kouba D.J.,
Nousari C.H.
Publication year - 2003
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2003.05671.x
Subject(s) - henoch schonlein purpura , pregnancy , gestation , medicine , purpura (gastropod) , vasculitis , immunology , gastroenterology , dermatology , biology , disease , ecology , genetics
Summary Henoch–Schönlein purpura (HSP) is an IgA‐mediated small vessel vasculitis which commonly involves the skin, gastrointestinal system and kidneys. Numerous HSP triggers have been identified, and pregnancy has been reported as an exacerbating factor. After a pregnant woman had been diagnosed as having new‐onset HSP, we reviewed all cases of immunofluorescence‐proven HSP evaluated by the Department of Dermatology at the Johns Hopkins Hospital between 1990 and 2002, and report three cases of HSP occurring during pregnancy. Two patients developed new‐onset HSP, one at 16 weeks gestation and one at 22 weeks, while the third developed a recurrence of HSP at 12 weeks gestation after 19 years of remission. We conclude that pregnancy may be a trigger for HSP onset or recurrence in susceptible individuals.