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Genital lichen sclerosus associated with morphoea or systemic sclerosis: clinical and HLA characteristics
Author(s) -
Farrell A.M.,
Marren P.M.,
Wojnarowska F.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2000.03717.x
Subject(s) - lichen sclerosus , scleroderma (fungus) , dermatology , sex organ , medicine , borrelia burgdorferi , autoimmune disease , systemic disease , disease , immunology , pathology , biology , antibody , inoculation , genetics
Although patients with both morphoea and lichen sclerosus have been reported previously, in the majority of these reports the lichen sclerosus has been extragenital. We report nine patients in whom genital lichen sclerosus coexisted with scleroderma spectrum disorders including seven with morphoea, one with morphoea and lichen planus, and one with systemic sclerosis. The clinical features, associated autoimmune disease, autoantibodies and HLA type are reported. Antibodies to Borrelia burgdorferi were not detected in any of the patients. The coexistence of these diseases raises a number of intriguing questions about the relationship between them.