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Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome
Author(s) -
DESCAMPS V.,
BOUSCARAT F.,
LAGLENNE S.,
ASLANGUL E.,
VEBER B.,
DESCAMPS D.,
SARAUX JL.,
GRANGE M.J.,
GROSSIN, M.,
NAVRATIL E.,
CRICKX B.,
BELAICH S.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1997.tb03795.x
Subject(s) - human herpesvirus 6 , medicine , anticonvulsant , fulminant , hypersensitivity reaction , immunology , phenobarbital , epilepsy , dermatology , viral disease , herpesviridae , virus , pharmacology , psychiatry
Summary Viral infections are thought to play a part in some cutaneous drug reactions. Human herpesvirus 6 (HHV6), which is the agent of exanthema subitum (sixth disease), has never been implicated in a drug reaction. We report a patient with severe phenobarbital‐induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection. We discuss the possible role of HHV6 in this reactive condition.