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Efficacy and safety of topical calcitriol (1,25‐dihydroxyvitamin D 3 ) for the treatment of psoriasis
Author(s) -
PEREZ A.,
CHEN T.C.,
TURNER A.,
RAAB R.,
BHAWAN J.,
POCHE P.,
HOLICK M.F.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1996.tb07608.x
Subject(s) - calcitriol , psoriasis , medicine , vaseline , placebo , dithranol , erythema , dermatology , vitamin d and neurology , surgery , pathology , alternative medicine , wound healing
Summary Plaque‐type psoriasis has been successfully treated with topical calcitriol. but there has been no term follow‐up study of the safety and efficacy of this calciotropic hormone. In a single‐centre study, patients with plaque or erythrodermic psoriasis were enrolled in a doubleblind, right/left comparison, placebo‐controlled study, and received 1·|mUg of calcitriol (15|mUg/g of Vaseline) per day, or a placebo consisting of Vaseline alone. A subset of these patients (n = 22), with at least 25% involvement, applied 0·1 g of calcitriol ointment/50 cm 2 on an area of from 2500 to 5000 cm 2 . Of the 84 patients enrolled in the double‐blind control study, 96·5% responded to topical calcitriol therapy, compared with 15·5% whose lesions improved with Vaseline alone, after 2 4 months. After completion of the double‐blind study. 22 patients applied calcitriol ointment (15 μg/g of Vaseline) to all of their lesions (up to 10 g of calcitriol ointment: 150μg calcitriol lesions showed either excellent or moderate clearing in 90‐9% of all cases. The remaining 9·1% of cases showed slight improvement of their lesions. No abnormalities in calcium metabolism were noted in any of the patients using topical calcitriol. None of the patients experienced any local cutaneous side‐effects. including six patients who applied calcitriol ointment to the face. Topical calcitriol is safe and effective for the treatment of psoriasis.