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The relationship between IgE‐mediated and cell‐mediated hypersensitivities in an unselected Danish population: The Glostrup Allergy Study, Denmark
Author(s) -
NIELSEN N.H.,
MENNÉ T.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1996.tb06967.x
Subject(s) - sensitization , immunoglobulin e , medicine , odds ratio , confidence interval , immunology , population , allergy , population study , allergen , antibody , environmental health
Summary In this study, we have assessed the relationship between IgE‐mediated and cell‐mediated hypersensitivities in an unselected population living in western Copenhagen, Denmark. A total of 793 subjects, aged 15–69 years, were studied. Measurements of total serum IgE prick tests with aeroallergens and patch tests with environmental haptens were performed in 561 (70·7% of 793) subjects. One or more positive prick tests were present in 28·4%, and contact sensitization occurred in 15·2%. When adjusted for the effects of sex and age, the probability of contact sensitization to one or more hapten was independent of serum IgE level (the odds ratio value (OR) = 1.0; 95% confidence interval (CI) = 0·7–1·4), and the probability of contact sensitization was independent of the number of positive prick tests (0R = 1·0; CI = 0·8–1·2). Contact sensitization appeared to be independent of enhanced IgE responsiveness in an unselected adult population.