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Skin grafts as pharmacological agents: pre‐wounding of the donor site
Author(s) -
KIRSNER R.S.,
FALANGA V.,
KERDEL F.A.,
KATZ M.H.,
EAGLSTEIN W.H.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1996.tb01164.x
Subject(s) - miami , medicine , dermatologic surgery , library science , dermatology , computer science , environmental science , soil science
Summary Initially thought to act as tissue replacement, cultured epithelial allografts arc now known to work by providing a potent stimultis for healing. In a similar fashion, we believe that traditional autografts may also provide a stimulus to help heal chronic wounds, thus acting as pharmacological agents for healing. We attempted to assess the possibility of augmenting the stimulatory properties of donor skin by initiating the healing process in the donor region prior to grafting. This was accomplished by pre‐wounding the donor area 3 days prior to harvesting the donor skin. We compared these ‘pre‐wounded’ grafts to those harvested immediately. Two patients underwent punch grafting for chronic leg ulceration. Half of the ulcer was grafted with donor skin harvested from an area that was pre‐wounded and the other half from freshly harvested skin. We evaluated each for improvement of granulation tissue and degree of edge effect (migration ofthe previously dormant wound edges). All the grafts did well. There was marked improvement in granulation tissue in the ulcer hed after grafting, and the obvious presence of an edge effect. The edge eflect vvas increased on the site where the pre‐wounded grafts were placed. It may be possible to augment the growth stimulatory properties of donor skin. This may offer therapeutic options in patients with chronic wounds.

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