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Transepidermmal water vapour loss is not increased during and following dithranol irritation
Author(s) -
SNATER E.,
JANSSEN E.A.A.J.,
VALK P.G.M.,
KERKHOF P.C.M.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb16947.x
Subject(s) - dithranol , transepidermal water loss , erythema , irritation , dermatology , psoriasis , medicine , pathology , stratum corneum , immunology
Summary Dithranol is established as a very successful treatment for psoriasis. Its main disadvantages are irritation and staining at sites of application. The aim of the present study was to elucidate further the mechanism of dithranol‐induced irritation, in particular to what extent this is related to an impairment of the skin barrier. Dithranol 3% in cream, paste and petrolatum was applied to the forearm skin of 20 volunteers and left in situ for 1 h. Transepidermal water loss (TEWL) was measured during a period of 2 weeks following dithranol application. In addition, a visual scoring system and colorimetry were used to assess erythema. The study showed conclusively that TEWL was not affected by the application of dithranol, even though pronounced erythema occurred.