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Allergic potential of neutrals in unmodified colophony, and a method for their separation from resin acids
Author(s) -
SADHRA S.,
FOULDS I.S
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb08627.x
Subject(s) - patch test , chemistry , chromatography , medicine , allergy , immunology
Summary An ion‐exchange fractionation technique for the separation of total resin acid and neutral fractions of unmodified colophony is described. The allergic potential of these fractions was assessed by patch testing colophony‐sensitive individuals, and this showed that both the neutral components and the resin acids play an important role in colophony sensitization. A greater frequency of positive reactions was obtained using the 60% colophony patch test preparation compared with the currently recommended 20% colophony preparation. Furthermore, some individuals were found to produce positive reactions to only the neutral components in colophony. We suggest that the use of a colophony patch test battery comprising resin acids, neutrals, oxidized resin acid and some colophony derivatives, will facilitate detection of colophony‐sensitive individuals. Moreover, we consider that this will help to provide a better estimate of the prevalence of colophony dermatitis, which is currently underestimated.