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Elevated cyclic adenosine monophosphate phosphodiesterase activity in peripheral blood mononuclear leucocytes from children with atopic dermatitis
Author(s) -
SAWAI T.,
IKAI K.,
UEHARA M.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb08619.x
Subject(s) - atopic dermatitis , medicine , peripheral blood mononuclear cell , phosphodiesterase , cyclic adenosine monophosphate , immunology , peripheral blood , adenosine , endocrinology , enzyme , biology , biochemistry , receptor , in vitro
Summary We examined peripheral blood mononuclear leucocyte cyclic adenosine monophosphate phosphodiesterase (cAMP‐PDE) activity in 80 children (aged 2‐12 years) with atopic dermatitis. The enzyme activity (35.1 ± 18.6U) in children with atopic dermatitis was significantly higher than that (19.1 ± 12.6U) in age‐matched non‐atopic controls. There was no significant difference in the cAMP‐PDE activity between children with mild atopic dermatitis and children with severe atopic dermatitis. These findings support the view that elevation of peripheral mononuclear leucocyte cAMP‐PDE actvity in patients with atopic dermatitis is a gene‐associated abnormality.