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The expression of c‐erbB‐2 protein in the keratinocytes of oral mucosal lichen planus
Author(s) -
KILPI A.,
RICH A.M.,
KONTTINEN Y.T.,
READE P.C.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb06915.x
Subject(s) - stratum spinosum , oral lichen planus , immunohistochemistry , epithelium , pathology , biology , monoclonal antibody , oral mucosa , neoplastic transformation , microbiology and biotechnology , keratinocyte , cancer research , antibody , medicine , immunology , cell culture , carcinogenesis , cancer , stratum corneum , genetics
Summary The expression of the c‐crbB‐2 protein was studied in the keratinocytes from patients with: (i) oral mucosal lichen planus (OLP) ( n =2(S): (ii) oral mucosal squamous cell carcinoma (OMSCC) which had arisen in mucosa affected by OLP ( n =5); and (iii) normal oral mucosa ( n =5). C‐erbB‐2 protein was expressed on the cell membranes of the keratinocytes of nucleated epithelium in the stratum spinosum. The antigenic determinant recognized represents the cytoplasmic domain of a cell surface receptor which binds an as yet uncharacterized heparin binding ligand of unknown function. 1.2 The specimens from the live normal subjects showed positive immunohistochemical staining with the monoclonal c‐erbB‐2 protein antibody, the OMSCC specimens were negative, and 23 of 26 of the OLP specimens were positive. The lack of c‐cerbB‐2 expression in the three OLP and in the five OMSCC specimens may indicate a genetic alteration, or masking of the expression of c‐cerbB‐2 . The absence of expression in OLP specimens might be an indicator of the possibility of future neoplastic transformation.