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Pyridoxine in atopic dermatitis
Author(s) -
MABIN D.C.,
HOLLIS S.,
LOCKWOOD J.,
DAVID T.J.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb02752.x
Subject(s) - medicine , atopic dermatitis , pyridoxine , placebo , dermatology , erythema , clinical trial , atopy , randomized controlled trial , allergy , pyridoxine hydrochloride , immunopathology , immunology , alternative medicine , pathology
Summary A previous study has reported benefit when pyridoxine hydrochloride was given to patients with atopic dermatitis. To investigate this in children, we performed a randomized, double‐blind, parallel‐group, placebo‐controlled trial. Forty‐eight children with moderate or severe atopic dermatitis were recruited and, of those who completed the study, 19 received pyridoxine hydrochloride 50 mg once daily for 4 weeks and 22 received placebo. Disease activity was monitored by clinical severity scores measuring the extent and degrees of erythema recorded by the investigator and symptom scores (daytime itch and nocturnal sleep disturbance) recorded by parents. There was no statistically significant difference between the two groups at the end of treatment. We have been unable to demonstrate clinical benefit from pyridoxine supplementation in children with atopic dermatitis.