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Prognostic value of Ki67 antigen expression in basal cell carcinomas
Author(s) -
HEALY E.,
ANGUS B.,
LAWRENCK C.M.,
REES J.L.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb02748.x
Subject(s) - value (mathematics) , medicine , basal (medicine) , dermatology , library science , computer science , insulin , machine learning
Summary Recurrence of basal cell carcinoma (BCC) following treatment is a common event and long‐term follow‐up of all patients presenting with a primary BCC has been recommended. Proliferation indices have been recognized as important prognostic factors in several tumour types in a variety of cancer systems, being significantly elevated in more aggressive lesions. We have examined 51 BCCs (17 non‐recurrent tumours [group 1]. 17 original tumours which later recurred [group 2‐0]. and the corresponding 17 recurrent specimens [group 2‐R] for Ki67 antigen expression, a proliferalionassociated antigen using immunohistochemistry with the monoclonal antibody MIB1. There was a significant increase in the percentage positive for MIB1 in the Group 2‐0 as compared with the group 1 BCCs (P