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Palmoplantar keratoderma with an unusual composition of stratum corneum and serum sterol derivatives: a new entity?
Author(s) -
BARLAG K.E.,
GOERZ G.,
RUZICKA T.,
SCHÜRER N.Y.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb02721.x
Subject(s) - stratum corneum , palmoplantar keratoderma , ichthyosis , keratoderma , sterol , cholesterol , corneocyte , hyperkeratosis , chemistry , biochemistry , medicine , endocrinology , biology , gene , genetics
Summary Little is known about the aetiology and pathogenesis of the different types of inherited and acquired palmoplantar keratodermas. We describe a condition of painful palmoplantar keratoderma with an altered stratum corneum lipid pattern which may be responsible for the excessive cornilication. Plantar stratum corneum lipids were analysed by quantitative thin‐layer chromatography. Serum lipids, and the activities and gene loci of the enzymes serum steroid sulphatase and arylsulphatase C were also determined. Examination revealed that both the stratum corneum and the serum cholesterol sulphate (CS) content were significantly elevated in comparison with the stratum corneum cholesterol ester content. The cholesterol content was unchanged compared with controls. Serum activities of steroid sulphatase and arylsulphatase C were decreased, but not to the extent found in recessive X‐linked ichthyosis. Their gene loci did not show any deletions. This unique distribution of stratum corneum sterol derivatives, reflected by the elevated serum CS concentration, may contribute to the altered structural and functional properlies of intercellular lipid lamellae within the stratum corneum of this type of keratoderma.