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Solitary giant xanthogranuloma and benign cephalic histiocytosis — variants of juvenile xanthogranuloma
Author(s) -
ZRLGER B.G.,
ZELGER B.,
STEINER H.,
MIKUZ G.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb02712.x
Subject(s) - juvenile xanthogranuloma , histiocytosis , medicine , histiocytosis x , juvenile , dermatology , pathology , histiocyte , biology , disease , genetics
Summary Sequential biopsies taken from a patient with a solitary giant xanthogranuloma, an exaggerated macronodular (>5 cm in diameter) variant of juvenile xanthogranuloma, and from a patient with benign cephalic histiocytosis, revealed a characteristic time sequence of histopathological findings. Early stages of the diseases showed a monomorphous infiltrate of mononuclear vacuolated histiocytes positive for KiM1p. HAM56 and factor XIIIa and were characterized by clusters of comma‐shaped bodies. This was followed by a polymorphous mixture of various mononuclear and mullinucleate histiocytes additionally labelling with KP1 (CD68) and, in occasional cells, for the adherence of peanut agglutinin. A variety of ultrastructural changes were found, including dense and regularly laminated bodies or lipid droplets. Our findings indicate that both entities are variants of a xanthogranulomatous reaction.