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Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata
Author(s) -
HARA M.,
HUNAYAMA M.,
AIBA S.,
SUETAKE T.,
WATANABE M.,
TANAKA M.,
TAGAMI H.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb02504.x
Subject(s) - medicine , alopecia areata , vitiligo , scalp , erythema , dermatology , discoid lupus erythematosus , hyperkeratosis , keratosis , pathology , lupus erythematosus , immunology , antibody
Summary We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54‐year‐old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC‐Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC‐Ag. We suggest that an immune‐mediated mechanism underlies the development of AP in this patient.