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Plasma levels of 8‐methoxypsoralen after bath‐PUVA for psoriasis: relationship to disease severity
Author(s) -
GÓMEZ M. I.,
AZAÑA J. M.,
ARRANZ I.,
HARTO A.,
LEDO A.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb02489.x
Subject(s) - psoralen , psoriasis , puva therapy , methoxsalen , medicine , dermatology , plasma levels , chemistry , biochemistry , dna
Summary Plasma levels of 8‐methoxypsoralen (8‐MOP) were determined by high‐pressure liquid chromato‐graphy in 19 patients with psoriasis who were receiving bath‐PUVA treatment, at different time points after the psoralen bath. The levels of 8‐MOP varied between < 5 ng/ml (lower limit of detection) and 34 ng/ml, and we found a relationship between the plasma psoralen levels and the severity of the disease.