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Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial
Author(s) -
SIEG P.,
DOMARUS H.,
ZITZEWITZ V.,
IVEN H.,
FÄRBER L.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb00728.x
Subject(s) - triamcinolone acetonide , medicine , corticosteroid , oral lichen planus , randomized controlled trial , clinical trial , dermatology , oral administration , surgery
Summary The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator‐blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish‐and‐spit medication for 5 min three times daily) or a corticosteroid oral paste (triamcinolone acetonide). The duration of treatment was 6 weeks. Thereafter, patients on corticosteroid therapy were treated with CyA. Only slight, transient clinical improvement was observed in both groups after 6 weeks of treatment, compared with baseline. No significant differences could be demonstrated between the two groups. CyA therapy following corticosteroid treatment did not produce any further clinical improvement. During follow‐up of the disease for up to 1 year after treatment, neither the CyA nor the corticosteroid group exhibited long‐term improvement in disease activity. Contradictory results from earlier reports are discussed.