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Biological activity of vitamin D analogues in the skin, with special reference to antipsoriatic mechanisms
Author(s) -
KERKHOF P.C.M.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb00710.x
Subject(s) - psoriasis , vitamin d and neurology , medicine , vitamin , inflammation , therapeutic modalities , dermatology , treatment modality , keratin , immunology , pharmacology , pathology
Summary Active vitamin D 3 modulates epidermal growth, keratinization and inflammation, and various vitamin D 3 analogues have been shown to be effective in the treatment of psoriasis. These analogues now provide a useful addition to the therapeutic modalities available for the treatment of psoriasis. Epidermal hyperproliferation, abnormal keratinization and inflammation are the well‐established hallmarks of the psoriatic plaque. The aim of this review is to provide an update of information on the cell biological effects of vitamin D 3 , and the influence of vitamin D analogues on the pathomechanisms of psoriasis.