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Improved prediction of the minimal phototoxic dose in PUVA therapy
Author(s) -
SAKUNTABHAI A.,
MATTHEWS J.N.S.,
FARR P.M.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb13107.x
Subject(s) - newcastle upon tyne , dermatology , medicine , classics , library science , history , art history , computer science
Summary In an attempt to improve the prediction of PUVA erythemal sensitivity, we have examined, in 2 51 patients, the relationship between the minimal phototoxic dose (MPD) and a number of variables, including skin type, ingested dose of 8‐methoxypsoralen (8‐MOP) and history of previous PUVA treatment. The MPD was determined by phototesting 2 h after ingestion of crystalline 8‐MOP. given at a standard dose of 0–6 mg/kg (calculated to the nearest 10 mg). No reaction to the highest dose of UVA used for phototesting occurred in 16% of cases; the dose of 8‐ MOP was significantly associated with non‐response. In the patients in whom an erythemal response was obtained, a significant association was found between the MPD and the variables of skin type, ingested dose of 8‐MOP. and history of previous PUVA treatment. Thus, by taking these factors into account, a more accurate prediction can be made of an individual patient's erythemal sensitivity to PUVA than relying on skin type alone. That erythemal sensitivity is affected by the ingested dose of 8‐MOP (even when all patients received 0–6 mg/kg) suggests that conventional psoralen dosing according to body weight is not ideal.