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Hair follicle expression of 1,25‐dihydroxyvitamin D 3 receptors during the murine hair cycle
Author(s) -
REICHRATH J.,
SCHILLI M.,
KERBER A.,
BAHMER F.A.,
CZARNETZKI B.M.,
PAUS R.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb08547.x
Subject(s) - hair follicle , hair cycle , receptor , endocrinology , medicine , hair loss , microbiology and biotechnology , biology , hair disease , dermatology , genetics
Summary Because the hair follicle is a highly hormone‐sensitive miniorgan, the role of hormones produced locally in the skin in the control of hair growth deserves systematic analysis. It has been shown previously that the potent steroid hormone 1,25‐dihydroxyvitamin D 3 (1,25‐D 3 ) modulates growth and differentiation of keratinocytes via binding to a high‐affinity nuclear vitamin D receptor (VDR). In this study, we have examined the in situ expression of VDR during the murine hair cycle. VDR expression was detected immunohistochemically. To obtain defined stages of the murine hair cycle, hair growth was induced by depilation in C57 BL‐6 mice. In addition to the recognized VDR expression of outer root sheath keratinocytes, we detected VDR immunoreactive cells in the dermal papilla, the mesenchymal key structure of the hair follicle. Furthermore, VDR immunoreactivity in the nuclei of outer root sheath keratinocytes and in dermal papilla cells was stronger during anagen IV‐VI and catagen than during telogen and anagen I‐III. This suggests hair cycle‐associated changes in the expression of VDR, and points to a potential role for 1,25‐D 3 in hair follicle biology. Selected follicular cell populations may display hair cycle‐dependent sensitivity to 1,25‐D 3 stimulation.