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Cutaneous necrosis associated with the antiphospholipid syndrome and mycosis fungoides
Author(s) -
HILL V.A.,
WHITTAKER S.J.,
HUNT B.J.,
LIDDELL K.,
SPITTLE M.F.,
SMITH N.P.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb06890.x
Subject(s) - mycosis fungoides , lupus anticoagulant , medicine , pathology , thrombosis , lymphoma , antiphospholipid syndrome , antibody , necrosis , dermatology , immunology
Summary The development of extensive cutaneous necrosis in a patient with tumour‐stage mycosis fungoides is described. Skin biopsies showed a lymphomatous infiltrate, and thrombosis of dermal blood vessels. Investigation revealed the presence of anticardiolipin antibodies, a lupus anticoagulant, and low free protein S, which contributed to a prothrombotic state. Antiphospholipid antibodies have been detected in non‐Hodgkin's lymphoma, but clinical manifestations are uncommon. Such autoantibodies may be produced by neoplastic lymphoid cells. The frequency with which antiphospholipid antibodies occur in mycosis fungoides is currently unknown.