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Cyclosporin A in the treatment of chronic dermatitis of the hands
Author(s) -
REITAMO S.,
GRANLUND H.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb06886.x
Subject(s) - medicine , surgery , chemotherapy , dermatology
Summary The efficacy of cyclosporin A (CyA) treatment was studied in seven patients with chronic dermatitis of the hands. CyA was started at a daily dose of 2·5 mg/kg in five patients, and 1·25 mg/kg in two patients. In patients who responded to the treatment at 2·5 mg/kg/day, the daily CyA dose was reduced stepwise, to the lowest maintenance dose of 1·25 mg/kg. In patients who did not respond, the dose was increased, to a maximum of 5 mg/kg/day. The patients were treated for 2–16 weeks. In six of the seven patients the dermatitis responded to CyA treatment within a few weeks. No response was seen with a starting dose of 1·25 mg/kg/day. In three of the five patients with a starting dose of 2·5 mg/kg/day, the daily CyA dose could be reduced to 1·25–2 mg/kg/day. After stopping CyA treatment, the dermatitis recurred during follow‐up in three patients, three remained in remission, and one patient was not available for study. Treatment‐related side‐effects occurred in three patients. CyA treatment had to be stopped in one patient due to headache. The present study suggests that CyA could be a useful treatment for chronic dermatitis of the hands not responding to conventional therapy.