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Suppression of murine melanoma growth with a combination of microwave hyperthermia and local injection of interleukin 2
Author(s) -
NAKAYAMA J.,
URABE A.,
TOYOFUKU K.,
TANIGUCHI S.,
HORI Y.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb03408.x
Subject(s) - hyperthermia , infiltration (hvac) , melanoma , medicine , microwave heating , interleukin 2 , interleukin , cancer research , pathology , immunology , cytokine , microwave , materials science , quantum mechanics , physics , composite material
Summary Local microwave hyperthermia in combination with local injections of interleukin 2 (IL‐2) was found to exert a remarkable suppressive effect on murine melanoma growth. Both of these therapeutic modalities caused marked tumour infiltration with natural killer cells. After microwave hyperthermia or IL‐2 injection alone there was minimal T‐cell infiltration, but T cells were more in evidence following combination therapy.