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An inflammatory eruption associated with recombinant human IL‐6
Author(s) -
FLEMING T. E.,
MIRANDO W. S.,
SOOHOO L. F.,
COOPER B. W.,
ZAIM M. T.,
LAZARUS H. M.,
ELMETS C. A.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb03393.x
Subject(s) - recombinant dna , medicine , cytokine , chemotherapy , immunology , carcinoma , cancer research , pathology , biology , biochemistry , gene
Summary Interleukin 6 (IL‐6) is an endogenous cytokine with multiple biological functions, including amplification of the inflammatory response. Recombinant human IL‐6, administered as part of a chemotherapeutic regimen, has recently been shown to cause regression of certain types of malignant tumours. We report a patient who developed a cutaneous eruption consisting of coalescent, erythematous, scaling macules and papules after administration of recombinant human IL‐6, given as part of her chemotherapy for ductal carcinoma of the breast.