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Pustular eruption after drug exposure: is it pustular psoriasis or a pustular drug eruption?
Author(s) -
SPENCER J.M.,
SILVERS D.N.,
GROSSMAN M.E.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb03389.x
Subject(s) - pustular psoriasis , drug eruption , medicine , dermatology , drug , pustulosis , psoriasis , pharmacology , surgery , osteomyelitis , osteitis
Summary Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding drug exposure, and rapid disappearance of the eruption after the drug is stopped, suggest a drug‐induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following drug administration. The history of preceding drug exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were drug‐induced.