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Photoprotective action of emollients in ultraviolet therapy of psoriasis
Author(s) -
HUDSONPEACOCK M.J.,
DIFFEY B.L.,
FARR P.M.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb02934.x
Subject(s) - psoriasis , dermatology , medicine , ultraviolet therapy , ultraviolet a , action (physics) , physics , quantum mechanics
Summary An in vitro technique was used to measure the monochromatic protection factors of all emollients available on prescription. The action spectra for ultraviolet erythema and erythema in psoralensensitized skin were used to calculate, for each cmollicnt, crythema protection factors relevant to UVB phototherapy and psoralen photochemotherapy, respectively. Of the 40 products tested. 22 (55%) had a UVB erythema protection factor ≥1·2 at an application density of 2 μ/cm 2 , and 31 (78%) at an application density of 4 μ/cm 2 . Fewer products, 25% at 2 μ/cm 2 and 50% at 4 μ/cm 2 , had a psoralen erythema protection factor ≥l·2. A protection factor of 1·2 is equivalent to a reduction in ultraviolet dose of 17%, and is thus likely to be of clinical importance. These results allow a choice of emollient products which may improve response by increasing transmission of radiation through psoriasis scale without a concomitant decrease in transmission due to a sunscreening action.