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Bullous pemphigoid in a 19‐year‐old woman. A case with unusual target antigens
Author(s) -
MORI O.,
HACHISUKA H.,
KUSUHARA M.,
SASAI Y.,
FUJIWARA S.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb02909.x
Subject(s) - bullous pemphigoid , exacerbation , medicine , eosinophilia , immunoglobulin e , antigen , dermatology , pathology , immunology , antibody
Summary We report a 19‐year‐old woman with typical clinical histological and immunofluorescence features of bullous pemphigoid. By immunoblotting, the serum was shown to detect antigens at 240 and 138 kDa. Elevated serum IgK levels were present, and there was a marked peripheral blood eosinophilia. The degree of eosinophilia correlated with small changes in the severity of the skin lesions, and the IgE level showed correlation with marked changes in severity. Another unusual feature was an exacerbation of her disease at the time of her first menses after the onset of the bullous pemphigoid.