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Thiopronine‐induced herpetiform pemphigus: report of a case studied by immunoelectron microscopy and immunoblot analysis
Author(s) -
VERDIERSEVRAIN S.,
JOLY P.,
THOMINE E.,
BELANYI PH.,
GILBERT D.,
TRON F.,
LAURET PH.
Publication year - 1994
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1994.tb02908.x
Subject(s) - immunoelectron microscopy , pemphigus , dermatology , medicine , pathology , immunohistochemistry
Summary We report a case of herpetiform pemphigus induced by thiopronine. Direct immunoelectron microscopy performed on peribullous skin showed IgG deposits predominantly located in the extracellular portion of desmosomes. By immunoblot analysis using bovine tongue extracts as the antigen, the patient's serum recognized a 160‐kDa polypeptide which comigrated with desmoglein I. This study underlines the contribution of immunoblot analysis to the diagnosis of atypical cases of pemphigus, and confirms that herpetiform pemphigus may be a clinical variant of pemphigus foliaceus.