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Can cyclosporin A induce permanent remission of atopic dermatitis?
Author(s) -
SEPP N.,
FRITSCH P.O.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb15154.x
Subject(s) - medicine , atopy , atopic dermatitis , hypertrichosis , dermatology , allergy , eosinophilia , immunoglobulin e , gastroenterology , surgery , immunology , antibody
Three adult patients, wbo bad suffered from severe tberapy‐resistant atopic dermatitis since childbood, were treated witb long‐term (29,44 and 22 months) low‐dose (maintenance dose: 0.5–0.7 mg/kg) cyclosporin A (CyA). All responded rapidly witbin 3–5 weeks and exbibited only minor exacerbations during tbe first pbases of therapy. No relapse occurred in any of the patients after drug withdrawal. All patients remained symptom‐free, except for occasional very mild and easily manageable localized lesions, for follow‐up periods of 34, 13 and 22 months. Side‐effects were minimal or tolerable (mild by pertricbosis in two patients, a slight decrease of creatinine clearance in one). In contrast with the clinical improvement, all atopy‐related parameters such as blood eosinophilia, elevated IgE levels and specific IgE (RAST) reactivity remained essentially unchanged, as were skin dryness and stigmata of atopy. It is concluded tbat long‐term low‐dose CyA treatment may lead to permanent or long‐term total or subtotal remission of atopic dermatitis.