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The anticonvulsant hypersensitivity syndrome
Author(s) -
HANDFIELDJONES S.E.,
JENKINS R.E.,
WHITTAKER S.J.,
BESSE C.P.,
MCGIBBON D.H.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb03523.x
Subject(s) - anticonvulsant , medicine , dermatology , pharmacology , epilepsy , psychiatry
Summary Anticonvulsants can cause a characteristic hypersensitivity reaction. This multisystem reaction typically presents as fever, mucocutaneous eruptions, lymphadenopathy and hepatitis. There is cross‐reactivity between different anticonvulsants. which complicates subsequent therapy. We report three cases to illustrate both the typical features, and less common complications, of this under‐recognized and life‐threatening syndrome.