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Low‐dose ultraviolet‐B irradiation depletes human epidermal Langerhans cells
Author(s) -
MURPHY G.M.,
NORRIS P.G.,
YOUNG A.R.,
CORBETT M.F.,
HAWK J.L.M.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb03330.x
Subject(s) - erythema , human skin , in vivo , irradiation , chemistry , medicine , dermatology , biology , genetics , physics , microbiology and biotechnology , nuclear physics
Summary We have examined the effects of low‐dose monochromatic UVB irradiation (295±5 nm), biologically equivalent to that generally incident on the skin during a 12‐session sun‐bed course, on the expression of the CDla epidermal Langerhans cell surface marker in human skin in vivo . In five subjects, 1.5 minimal erythema doses (MEDs) at 295 nm depleted its expression by 50%. In five further subjects, a single 1.5 MED dose, 1.5 MEDs in 10 equal fractions on alternate days, and a single 1.5 MED dose at one‐tenth the previously used irradiance, delivered to separate sites, also led to variable but significant depletion of CD la expression of around‐30–50%. Thus, low‐dose UVB irradiation, whether received rapidly or slowly, appears significantly and approximately equally to deplete human epidermal Langerhans cell numbers as measured by CDla expression.