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Age‐related proliferative activity in dermal melanocytic naevi detected by PCNA/cyclin expression
Author(s) -
TU* P.,
MIYAUCHI S.,
MIKI Y.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb03313.x
Subject(s) - proliferating cell nuclear antigen , epidermis (zoology) , basal (medicine) , nevus , pathology , biology , immunohistochemistry , monoclonal antibody , melanocytic nevus , ageing , antibody , medicine , melanoma , cancer research , immunology , anatomy , genetics , insulin , endocrinology
Summary A monoclonal antibody was used to demonstrate proliferating cell nuclear antigen in routine, formalin‐fixed, paraffin‐embedded tissue sections of dermal melanocytic naevi, including naevus naevocellularis partim lipomatodes, in different age‐groups. The labelling indices of the melanocytic naevus cells were < 1% of those in the overlying epidermal basal cells, and showed a statistically significant decrease with ageing, and also in naevus naevocellularis partim lipomatodes, whereas the indices of the basal cells in the overlying interfollicular epidermis did not show any age‐related changes.