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Difference in clinical features and HLA antigens between familial and non‐familial vitiligo of non‐segmental type
Author(s) -
ANDO I.,
CHI HI.,
NAKAGAWA H.,
OTSUKA F.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb03167.x
Subject(s) - vitiligo , medicine , human leukocyte antigen , family history , dermatology , immunology , pigmentation disorder , antigen
Summary Of 131 patients with non‐segmental vitiligo studied, 29 (22%) had a family history of this disorder. The clinical features and HLA antigens were assessed, and a comparison made between patients with familial and those with non‐familial, non‐segmental vitiligo. Familial patients developed skin lesions significantly earlier than non‐familial patients. There was a significant association between HLA‐B46 and familial non‐segmental vitiligo, whereas HLA‐A31 and CW4 were found in non‐familial patients. The differences in clinical features and HLA phenotypes suggest heterogeneity in the pathogenic process between familial and non‐familial vitiligo patients.