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Fanconi's anaemia associated with multicentric Bowen's disease and decreased NK cytotoxicity
Author(s) -
LEBBÉ C.,
PINQUIER L.,
RYBOJAD M.,
CHOMIENNE C.,
OCHONISKY S.,
MICLEA J. M.,
GLUCKMAN E.,
MOREL P.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00497.x
Subject(s) - bowen's disease , cytotoxicity , fanconi anemia , medicine , disease , cancer research , virology , dermatology , biology , genetics , basal cell , dna , dna repair , in vitro
Summary We report a patient with Fanconi's anaemia and multiple lesions of vulvo‐anal Bowen's disease. She was thrombocytopenic and lymphopenic. and NK‐mediated cytotoxicity was undetectable. The vulvar lesions did not contain papillomavirus DNA. In vitro studies showed a possible benefit from acitretin treatment on bone marrow stem cells. However, low‐dose acitretin given for 14 months did not prevent the development of an anal squamous carcinoma. Acitretin therapy was, however, associated with a sustained rise in the platelet count.