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The theràpeutic effect of intralesional interferon in classical Kaposi's sarcoma
Author(s) -
TRATTNER A.,
REIZIS Z.,
DAVID M.,
INGBER A.,
HAGLER J.,
SANDBANK M.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00490.x
Subject(s) - medicine , sarcoma , interferon , alpha interferon , kaposi's sarcoma , interferon alfa , prospective cohort study , gastroenterology , surgery , immunology , pathology , human herpesvirus
Summary Interferon alpha‐2a, which has antineoplastic, antiviral, immunomodulatory, and antiangiogenic effects, was evaluated in a prospective study, treating 10 lesions of patients with classical Kaposi's sarcoma. Ten patients received injections of interferon alpha‐2a intralesionally in a dose of 3 million units three times weekly for 4 weeks, and in a variable dose for 4 more weeks. Two of the patients had a complete response, and in one of these, distant lesions also responded. Seven had a partial response, and one did not respond. The treatment was generally well tolerated. The results of our study support the use of interferon in the therapy of classical Kaposi's sarcoma, although it would appear that to achieve maximum efficacy, a longer period of treatment is needed.