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Lichenoid skin lesions as a sign of β 2 ‐microglobulin‐induced amyloidosis in a long‐term haemodialysis patient
Author(s) -
SATO K.C.,
KUMAKIRI M.,
KOIZUMI H.,
ANDO M.,
OHKAWARA A.,
FUJIOKA Y.,
KON T.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00266.x
Subject(s) - medicine , beta 2 microglobulin , amyloidosis , sign (mathematics) , term (time) , dermatology , pathology , mathematical analysis , physics , mathematics , quantum mechanics
Summary We report a case of β 2 ‐microglobulin‐induced amyloidosis. The patient was a 40‐year‐old man suffering from non‐amyloid nephropathy, who had been treated by haemodialysis for 20 years. Lichenoid skin lesions, consisting of groups of pin‐head‐sized shiny papules, were present on the arms and trunk. On histological examination, amyloid deposits were present, principally in the dermal papillae, hut also around the sweat ducts and hair follicles. The amyloid displayed potassium‐permanganate‐resistant Congo red affinity, and green birefringence under polarized light, Immuno‐histochemically, β 2 ‐microglobulin was demonstrated in the lesions, confirming that they were a manifestation of β 2 ‐microglobulin‐associated amyloidosis. Skin lesions of this type have not been reported previously in β 2 ‐microglobulin‐associated amyloidosis.